Rothamsted Research

where knowledge grows


Michael Beale

Principal Investigator
Plant Biology & Crop Science
+44 (0) 1582 763 133 ext: +44 1582 938125
Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
Past Projects
Principal Investigator
  • Metabolomic technology development and the departmental analytical spectroscopy service
  • Met-Ex - The Metabolite Standards Repository and Exchange
Project Leader
  • New drugs from old: A phytochemical genetics and pharmacological screen of salix

a) Papers in refereed journals

1. Beale, M.H. and MacMillan, J. (1980). Mechanism and Stereochemistry of Conjugate Reduction of Enones from Gibberellins A3 and A7. J.C.S. Perkin I, 877-884.

2 Beale, M.H., Gaskin, P., Kirkwood , P.S. and MacMillan, J. (1980). Partial Synthesis of Gibberellin A9 and [3α- and 3β-2H1] Gibberellin A9; Gibberellin A5 and [1β,3-2H2 and -3H2] Gibberellin A5; and Gibberellin A20 and [1β,3α-2H2 and -3H2] Gibberellin A20. J.C.S. Perkin I, 885-891.

3 Beale, M.H. and MacMillan, J. (1980). Partial Synthesis of Gibberellin A7 from Gibberellin A3. J. Chem. Research (S), 289, J. Chem. Research (M) 3536-3543

4 Kutney, J.P., Beale, M.H. et al. (1980). Tripdiolide from Tissue Cultures of Tripterygium wilfordii. Heterocycles, 14, 1465-1467.

5 Beale, M.H. and MacMillan, J. (1981). Partial Synthesis of [2α-2H]- and [2α-3H] Gibberellin A29 and [2α-2H,-15,17-3H4] Gibberellin A5 from Gibberellin A3. J.C.S. Perkin I, 394-400.

6 Beale, M.H. and MacMillan, J. (1981). Preparation of 2- and 3-Substituted Gibberellin A9 and A4 for Bioassay. Phytochemistry, 20, 693-701.

7 Kutney, J.P., Beale, M.H. et al. (1981). Isolation and Characterisation of Natural Products from Plant Tissue Cultures of Maytenus buchananii. Phytochemistry 20, 653-657.

8 Kirkwood , P.S., MacMillan, J. and Beale, M.H. (1982). Partial Synthesis of [17-13C; 15,17-3H] Gibberellin A29 from Gibberellin A3. J.C.S. Perkin I, 699-706.

9 Beale, M.H., Bearder, J.R., Down, G.H., Hutchinson , M., MacMillan, J. and Phinney, B.O. (1982). The Biosynthesis of Kaurenolide Diterpenoids by Gibberella fujikuroi. Phytochemistry, 21, 1279-1287

10 Beale, M.H., Bearder, J.R., MacMillan, J., Matsuo, A. and Phinney, B.O. (1983). Diterpene Acids from Helianthus Species and their Microbiological Conversion by Gibberella fujikuroi, mutant B1-41a. Phytochemistry, 1983, 22, 875.

11 Beale, M.H., MacMillan, J., Spray, C., Taylor , D.A. and Phinney, B.O. (1984). The Synthesis of 2,2-Dialkylgibberellins. J.C.S. Perkin 1, 541-545.

12 Beale, M.H., Bearder, J.R., Graebe, J.E., Hedden, P. and MacMillan, J. (1984). Gibberellin A58 and ent-6α,7α,12α-Trihydroxykaur-16-en-19-oic Acid from Seeds of Cucurbita maxima. Phytochemistry, 1984, 23, 565-567.

13 Hedden, P., Graebe, J.E., Beale, M.H., Gaskin, P. and MacMillan, J. (1984). The Biosynthesis of 12-Hydroxylated Gibberellins in a Cell-free system from Cucurbita maxima endosperm. Phytochemistry, 1984, 23, 569-574.

14 Beale, M.H. (1985). Conjugate Addition of Lithium Methylcuprates to a Gibberellin-1(10)-en-2-one. Preparation of 10-epi-Gibberellin A53. J.C.S. Perkin 1, 1985, 1147-1150.

15 Beale, M.H. (1985). SN2 and SN2' Alkylation of some Gibberellin Allylic Lactones by Lithium Methylcuprates. J.C.S. Perkin 1, 1151-1156. )

16 Beale, M.H., MacMillan, J. and Makinson, I.K. (1986). An Efficient Synthesis of 2-Hydroxy-gibberellins. Tetrahedron Letters, 27(9), 1109-1112.

17 Knox, J.P., Beale, M.H., Butcher, G.W. and MacMillan, J. (1987). Preparation and characterisation of Monoclonal Antibodies which recognise different Gibberellin Epitopes. Planta, 170, 86-91.

18 Fowles, A.M., Beale, M.H., Jones, D.N.M., MacMillan, J. and Willis, C.L. (1988). 2β-Alkyl Gibberellins A1 and A4. J.C.S. Perkin I, 1983-1991.

19 Beale, M.H. and MacMillan, J. (1988). The Biosynthesis of C5-C20 Terpenoid Compounds (1986). Natural Product Reports, 5(3), 247-264.

20 Knox, J.P., Beale, M.H., Butcher, G.W. and MacMillan, J. (1988). Monoclonal Antibodies to 13-Deoxy-Gibberellins. Plant Physiol., 88, 959-960.

21 Semenenko, F., Nester-Hudson, J., Beale, M.H. and MacMillan, J. (1990). New Monoclonal Antibodies to 3β-Hydroxy Gibberellins. Phytochemistry, 29, 1041-1045.

22 Beale, M.H. (1990). The Biosynthesis of the C5-C20 Terpenoids (1987). Natural Product Reports 7, 25-39.

23 Beale, M.H. (1990). The Preparation of Gibberellin Hapten-protein Conjugates 1. Conjugation via Carboxy methylenation at C-17. J.C.S. Perkin 1, 925-929.

24 Beale, M.H. (1990). The Biosynthesis of the C5-C20 Terpenoids (1988). Natural Product Reports, 7, 387-407.

25 Hooley, R., Beale, M.H. and Smith, S.J. (1991). Gibberellin perception at the plasma membrane of A. fatua Aleurone Protoplasts using GA-Sepharose Probes. Planta, 183, 274.-280

26 Beale, M.H., MacMillan, J., Makinson, I. and Willis, C.L. (1991). Two efficient partial syntheses of Gibberellin A81 from Gibberellin A3. J.C.S. Perkin I 1191-1195.

27 Beale, M.H. (1991). The Biosynthesis of the C5-C20 Terpenoids (1989). Natural Product Reports, 8, 441-454.

28 Beale, M.H. (1991). The Preparation of Gibberellin Hapten-protein Conjugates. 2. Conjugation via the Addition of α,ω dithiols to C-16-enes. J.C.S. Perkin I., 2559-2563.

29 Beale, M.H., Hooley, R., Smith, S.J., and Walker, R.P. (1992). Photoaffinity Probes for Gibberellin-binding Proteins. Phytochemistry, 31, 1459-1464.

30 Walker , R.P., Beale, M.H. and Hooley, R. (1992). Photoaffinity labelling of MAC 182, a Gibberellin-specific Monoclonal Antibody. Phytochemistry, 31, 3331-3335.

31 Nester-Hudson, J.E., Beale, M.H., and MacMillan, J. (1992). Large-scale Purification and Preliminary Structural Studies of MAC 182, a Gibberellin-binding Monoclonal Antibody. Phytochemistry, 31, 3337-3339.

32 Smith, S.J., Walker , R.P., Beale, M.H. and Hooley, R. (1993). Biological Activity of Some Gibberellins and Gibberellin Derivatives in Aleurone Cells and Protoplasts of Avena fatua. Phytochemistry, 33, 17-20.

33 Hooley, R., Smith, S.J., Beale, M.H. and Walker, R.P. (1993). In vivo Photoaffinity Labelling of Gibberellin-binding Proteins in Avena fatua Aleurone. Aust. J. Plant Physiol., 20. 573-584. .

34 Ward, J.L., Reynolds, G.J., Hooley, R. and Beale, M.H. (1993) Synthesis, stability and biological activity of 19-deoxy-gibberellins A1 and A3. Phytochemistry, 34, 1219-1224

35 Ward, J.L. and Beale, M.H. (1993) Synthesis and biological activity of stereochemically locked derivatives of jasmonic acid. J.Chem.Soc. Perkin Trans. I. 2397-2382.

36 Beale, M.H., Chen, A., Harrison , P.A. and Willis, C.L. (1993) A. Facile Aromatisation of Abscisic Acid. J.Chem.Soc. Perkin Trans. I . 3061-3064.

37 Beale, M.H. and Sponsel, V.M. (1993) Future Prospects in Plant Hormone Research. J. Plant Growth Regul. 12, 227-235.

38 Allan, A.C., Fricker, M.D., Ward, J.L., Beale, M.H. and Trewavas, A. J. (1994) Two Transduction Pathways Mediate Rapid Effects of Abscisic Acid in Commelina Guard Cells. Plant Cell, 6, 1319-1328.

39 Walker , R.P., Waterworth, W.M., Beale, M.H. and Hooley, R. (1994) Gibberellin photoaffinity labelling of wild oat (Avena fatua L.) aleurone protoplasts. Plant Growth Regul. 15, 271-279 (30,0,10)

40 Koda, Y., Ward, J.L. and Beale, M. H. (1995) Biological Activity of Methyl 7-methyljasmonates. Phytochemistry, 38, 821-823.

41 Ward, J. L. and Beale, M.H. (1995) Caged Plant Hormones. Phytochemistry, 38, 811-816.

42 Beale, M. H., Hooley,R., Lewis, M.J., Smith, S.J. and Ward. J (1995) Radioiodinated gibberellin Photoaffinity Probes. J. Chem. Soc Perkin Trans I, 657-663.

43 Croker, S.J., Gaskin, P., Beale, M.H. and Lenton, J.R. (1995) ent-3α-hydroxykaur-16-ene and ent-17-hydroxykaur-15-ene in Paclobutrazol-treated wheat seedlings. Phytochemistry, 39, 11-14

44 Resende, M.L.V, Cooper, R.M., Flood, J. and Beale. M.H. (1995) The Role of Tannins and a Multiple phytoalexin Response in the Resistance of Cocoa (Threobroma cacao L.) to Verticillium dahliae. Phytoparasitica, 23, 59.

45 Cooper, R.M., Resende, M.L.V, Flood, J., Rowan M.G, Beale. M.H. and Potter, U., (1996) Detection and Cellular Location of Elemental Sulphur in Disease-resistant Genotypes of Threobroma cacao., Nature, 379, 159-162

46 Perez-Amador, M.A., Carbonell, J., Navarro, J.L., Moritz, T., Beale, M.H., Lewis, M.J. and Hedden, P. (1996) N4-Hexanoylspermidine, a New polyamine-related Compound that Accumulates during Ovary and Petal Senescence in Pea. Plant Physiol. 110, 1177-1186.

47 Bennett, M., Gallagher, M., Fagg, J., Bestwick, C., Paul, T., Beale, M.H. and Mansfield , J., (1996) The hypersensitive reaction, membrane damage and accumulation of autofluorescent phenolics in lettuce cells challenged by Bremia lactucae. Plant Journal, 9, 851-865

48 Resende, M.L.V, Flood, J. Ramsden, J.D. , Rowan M.G, Beale. M.H. and Cooper, R.M. (1996) Novel phytoalexins including elemental sulphur in the resistance of cocoa (Threobroma cacao L.) to verticillium wilt (Verticillium dahliae Kleb). Physiol Mol. Plant Pathol. 48, 347-359

49 Ward, J.L., Jackson , G., Beale, M.H. Gaskin. P., Hedden, P., Mander, L. N., Phillips, A. L., Seto, H., Talon, M., Willis, C. L., Wilson, T. M. And Zeevaart, J. A. D. (1997) Stereochemistry of oxidation of gibberellin 20-alcohols, GA15 and GA44, to 20-aldehydes by gibberellin 20-oxidases. Chem. Commun, 13-14

50 Beale, M.H., Loaring H., Peakman, T., Penny, M. and Willis, C.L. (1997) Unusual reactions of Methanesulphonyl Esters: Synthesis of 3α-methyl and 3β-methyl Gibberellin A20. J. Chem Soc Perkin Trans 1, 433-442.

51 Kohler, A. D., Beale, M. H., Rollason, R., Barratt, D. H. P., Lewis, M. J., Van der Meulen, R. M. and Wang, M. (1997) A radio-iodinated abscisic acid photoaffinity probe. J. Chem Soc Perkin Trans 1. 1543-1547.

52 Ward, J. L., Gaskin, P., Beale, M. H. , Sessions,R., Koda, Y. and Wasternack, C. (1997)Molecular Modelling, Synthesis and Biological Activity of Methyl 3-methyljasmonate and Related Derivatives. Tetrahedron, 53, 8181-8194.

53 Brown, R. L. G., Li Yan., Beale, M. H. and Hedden, P. (1998) Inhibition of gibberellin 3 b -hydroxylase by novel acylcyclohexanedione derivatives, Phytochemistry, 47,679-687

54 Wasternack, C., Ortel, B., Miersch, O., Kramell,R., Beale, M.H., Greulich, F., Feussner, I.., Hause, B., Krumm, T., Boland, W., Parthier, B. (1998) Diversity in octadecanoid-induced gene expression of tomato. J. Plant Physiol. 152, 345-352

55 Wasternack, C., Miersch, O., Kramell, R., Hause,B., Ward, J.L., Beale, M.H., Boland, W., Parthier, B. and Feussner, I. (1998) Jasmonic acid: biosynthesis, signal transduction and gene expression. Fett -Lipids, 100, 139-146

56 Lovegrove, A., Barratt, D. H. P., Beale, M.H. and Hooley, R. (1998) Gibberellin-photoaffinity labelling of two polypeptides in plant plasma membranes. Plant Journal, 15, 311-320

57 Beale, M. H. and Ward, J. L. (1998) Jasmonates: key players in the plant defence, Natural Product Reports, 15, 533-548

58 McLusky, S. R., Bennett, M.H., Beale, M.H., Lewis, M.J., Gaskin, P. and Mansfield, J. W. (1999) Cell-wall alterations and localised accumulation of feruloyl-3�-methoxytyramine in onion epidermis at sites of attempted penetration by Botrytis alliii are associated with actin polarisation, peroxidase activity and suppression of flavonoid biosynthesis. Plant Journal, 17, 523-534

59 Sessa, R.A, Bennett, M.H., Lewis ,M.J., Mansfield, J. W and Beale M.H (2000) Metabolite profiling of sesquiterpene lactones from Lactuca species. J. Biol. Chem. 275, 26877-26884

60 Williams, J.S., Hall, S. A., Hawkesford, M.J., Beale, M. H. and Cooper, R. M. (2002) Elemental Sulfur and Thiol Accumulation in Tomato and Defense against a Fungal Vascular Pathogen, Plant Physiology, 128, 150-159

61 Ward, J.L, Gaskin, P., Brown, R.G.S., Jackson, G.S., Hedden, P. Phillips, A. L., Willis, C. L. and Beale, M. H (2002) Probing the mechanism of loss of carbon-20 in gibberellin biosynthesis. Synthesis of gibberellin 3α,20-hemiactetal and 19,20-lactol analogues and their metabolism by a recombinant GA 20-oxidase. J. Chem Soc Perkin Trans 1, 232-241

62 Ward, J. L. and Beale, M. H. (2002) Synthesis of 4-hydroxy-3-methyl-2-(E)-butenyl diphosphate, a key intermediate in the biosynthesis of isoprenoids. J. Chem Soc. Perkin Trans 1, 710-712

63 Beale, M.H, Dupree, P., Lilley, K., Beynon, J., Trick, M., Clarke, J., Bevan, M., Bancroft, I., Jones, J., May, S., van de Sande, K. and Leyser, O (2002) GARNet, the Genomic Arabidopsis Resource Network, Trends in Plant Sciences,7, 145-147

64 Bennett, M.H., Mansfield, J.W., Lewis, M. J. and Beale, M. H. (2002) Cloning and expression of sesquiterpene synthase genes from lettuce (Lactuca sativa L) Phytochemistry, 60, 255-261

65 Prosser, I, Phillips A. L., Gittings S., Lewis, M.J., Hooper A. M., Pickett, J. A. and. Beale, M. H. (2002) (+)-(10R)-Germacrene A synthase from goldenrod, Solidago canadensis; cDNA isolation, bacterial expression and functional analysis, Phytochemistry, 60, 691-702

66 Hall, R, Beale, MH, Fiehn, O., Hardy, N., Sumner, L and Bino, R. (2002) Plant metabolomics: The missing link in functional genomic strategies Plant Cell , 14, 1437-1440

67 Ward, J. L., Harris, C., Lewis, J. and Beale, M. H. (2003) Assessment of 1H-NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. Phytochemistry, 62, 949-957

68 Garton S. , Michaelson , L. V. , Beaudoin, F. Beale , M.H. and Napier , J.A (2003) The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe. FEBS Letters, 538, 192-6

69 Bouwmeester, H. J., Matusova, R., Zhongkui, S., and Beale, M.H. (2003) Secondary metabolite signalling in host-parasite plant interactions. Current Opinion in Plant Biology, 6, 1-7.

70 Prosser, I. , Altug, I.G., Lewis, M.J., Phillips, A.L., Konig, W.A., Bouwmeester, H.J. and Beale, M.H. (2004) Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif. Archives Biochem. Biophys. 432, 136-144

71 Bino, R.J., Hall, R.D., Feihn, O, Beale, M.H. et al (2004) Potential of Metabolomics as a Functional Genomics Tool. Trends in Plant Science. 9, 418-425

72 Cornah, J.E., Germain, V., Ward, J.L., Beale, M.H., Smith, S.M. (2004) Lipid Utilisation, gluconeogenesis and seedling growth in Arabidopsis mutants lacking the glyoxylate cycle enzyme malate synthase. J. Biol. Chem., 279, 42916-42923

73 Naested H, Holm A, Jenkins T, Nielsen HB, Harris CA, Beale MH , Andersen M, Mant A, Scheller H, Camara B, Mattsson O, Mundy J (2004) Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development J Cell Science, 117, 4807-4818.

74 Rasha El-Kassas, Zaharaa Karam El-Din, Michael H. Beale, Jane L. Ward and Richard N. Strange. (2005) Bioassay-led identification of Myrothecium verrucaria and verrucarrin A as germination inhibitors of Orobanche crenata. Weed Research, 45, 211-219

75 G opalakrishnan, S., Beale, M.H., Ward, J.L. and Strange, R.N. (2005) Chickpea wilt: identification and toxicity of 8-O-methyl-fusarubin from Fusarium acutatum . Phytochemistry, 66, 1536-1539

76 Ian M. Prosser, Racheal J. Adams, Michael H. Beale, Nathan D. Hawkins, Andrew L. Phillips, John A. Pickett, and Linda M. Field (2006). Cloning and functional characterisation of a novel cis-muuroladiene synthase from black peppermint (Mentha x piperita) and direct evidence for a chemotype unable to synthesise farnesene. Phytochemistry, 67, (2006) 1564 -1571

77 Radoslava Matusova, Kumkum Rani, Francel W.A. Verstappen, Maurice C.R. Franssen, Michael H. Beale, and Harro J. Bouwmeester (2005) The Strigolactone Germination Stimulants of the Plant-parasitic Striga and Orobanche spp are Derived from the Carotenoid Pathway . Plant Physiol., 139, 920-934

78. Andrew J. Humphrey and Michael H. Beale. (2006) Strigol: Biogenesis and physiological activity. Phytochemistry 67, 636-640

79. John M. Baker, Nathaniel D. Hawkins, Jane L. Ward, Alison Lovegrove, Johnathan A. Napier, Peter R. Shewry and Michael H. Beale (2006)* A metabolomic study of substantial equivalence of field-grown GM wheat. Plant Biotechnology Journal 4(4), 381-392

80 Andrew J. Humphrey, Aimee M. Galster and Michael H. Beale Strigolatones in chemical ecology: waste products or vital allelochemicals? (2006) Natural Products Reports 23, 592-614

81 Michael H. Beale, Michael A. Birkett, Toby J.A. Bruce, Keith Chamberlain, Linda M. Field, Alison K. Huttly, Janet L. Martin, Rachel Parker, Andrew L. Phillips, John A. Pickett, Ian M. Prosser, Peter R. Shewry, Lesley E. Smart, Lester J. Wadhams, Christine M. Woodcock and Yuhua Zhang (2006) Aphid alarm pheromone produced by transgenic plants affects aphid and parasitoid behaviour. Proceedings of the National Academy of Sciences of the United States of America , 103 (27) 10509-10513

82 Sandra J. Hey, Stephen J. Powers, Michael H. Beale, Nathaniel D Hawkins, Jane L. Ward and Nigel G. Halford.(2006) Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase. Plant Biotechnology Journal. 4, 219-229

83. Paul Chilley, Stuart Casson, Petr Tarkowski, Nathan Hawkins, Kevin Wang, Patrick Hussey, Mike Beale, G�ran Sandberg and Keith Lindsey. (2006) The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signalling. Plant Cell,18, (11): 3058-3072

84 John Keon, John Antoniw, Raffaella Carzangia, Si�n Deller, Jane L Ward, John M Baker, Michael H Beale, Kim Hammond-Kosack and Jason J Rudd. (2006) Transcriptional adaptation of Mycosphaerella graminicola to programmed cell death (PCD) of its susceptible wheat host. Mol. Plant Microbe Int. 20, 178-193

85 Jane Ward, John Baker and Michael Beale. Recent applications of NMR Spectropscopy in Plant metabolomics (2006) FEBS Journal 274,(2007) 1126-1131

86 Peter Shewry, Jane L Ward, Michael H Beale, John Baker, Marcela Baudo, Johnathan Napier. Are GM and conventionally bred cereals really different? Trends in Food Science and Technology. 18. (2007) 201-209

87 L W. Sumner, A Amberg, D Barrett, M H. Beale, R. Beger, C A. Daykin, T W.-M. Fan, O Fiehn, R Goodacre, J L. Griffin, T Hankemeier, N Hardy, J Harnly, R Higashi, J Kopka, A N. Lane, J C. Lindon, P Marriott, A W. Nicholls, M D. Reily, J J. Thaden, M R. Viant (2007) . Proposed minimum reporting standards for chemical analysis: Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI) Metabolomics, 3, 211-221

88 Laurence J.M. Ducreux, Wayne L. Morris, Ian M. Prosser, Jenny A. Morris, Michael H. Beale, Frank Wright, Glenn, J Bryan, Pete E. Hedley, Mark A. Taylor (2008) Expression profiling of potato germplasm differentiated in quality traits leads to the identification of candidate flavour and texture genes. Journal Experimental Botany, 52, 4219-4232

 89 Jonathan R Howarth, Saroj Parmar, Janina Jones, Caroline E Shepherd, Delia-Irina Corol, Aimee M Galster, Nathan D Hawkins, Sonia J Miller, John M Baker, Paul J Verrier, Jane L Ward, Michael H Beale, Peter B Barraclough and Malcolm J Hawkesford.  (2008) Co-ordinated expression of amino acid metabolism pathway genes in response to N and S-deficiency during wheat grain-filling. Journal Experimental Botany, 59, 3675-3689

90 Ghannoum, O., Paul, M.P., Ward, J., Beale, M.H., Corol, D.I., and Conroy, J.P. (2008) The sensitivity of photosynthesis to phosphorus deficiency differs between C3 and C4 tropical grasses. Functional Plant Biology, 35 , 1-9 

91 Ana Carmen-Silva, Alfred Keys, Michael H Beale, Jane L Ward, John M Baker, Nathaniel D Hawkins, Maria Celeste Arrabaca and Martin J Parry. (2009) Drought stress increases the production of 5-hydroxynorvaline in two C4 grasses. Phytochemistry, 70, 664-671

92 Jingyuan Fu, Joost J B Keurentjes, Harro Bouwmeester, Twan America, Francel WA Verstappen, Jane L Ward, Michael H Beale, Ric C H de Vos, Martijn Dijkstra, Richard A Scheltema, Frank Johannes, Maarten Koornneef, Dick Vreugdenhil, Rainer Breitling & Ritsert C Jansen (2009), System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nature Genetics 41. 166-7

 93 Peter R Shewry, Fangjie Zhao, Godfrey B Gowa, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Nigel G Halford, Martin A Parry, Joel Abecasis (2009) Suphur nutrition differentially effects the distribution of asparagine in wheat grain. Cereal Science 50, 407-409.

94. Jane L. Ward, John M. Baker, Sonia J Miller, Catherine Deborde, Mickael Maucourt, Benoit Biais, Dominique Rolin, Annick Moing, Sofia Moco,Jacques Vervoort, Arjen Lommen, Hartmut Schäfer,  Eberhart Humpferand Michael H. Beale. An inter-laboratory comparison demonstrates that [1H]-NMR metabolite fingerprinting is a robust technique for collaborative plant metabolomic data collection Metabolomics, 2010, 6, 263-273 

95. Jane L. Ward, Silvia Forcat , Manfred Beckmann, Mark Bennett ,  Sonia J. Miller , John M. Baker , Nathaniel D. Hawkins, Corina Vermeer , Chuan Lu , Wanchang Lin , William M. Truman, Michael H. Beale , John Draper , John W. Mansfield  and Murray Grant (2010)  The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato. The Plant Journal, 63(3), 443-457. 

96. Rohan G. T. Lowe,  J. William Allwood, Aimee Galster, Martin Urban , Arsalan Daudi, Gail Canning, Jane L. Ward, Michael H. Beale and Kim E. Hammond-Kosack (2010) A combined 1H NMR and ESI-MS analysis to understand the basal metabolism of plant pathogenic Fusarium species, Molecular Plant-Microbe Interactions, 23(12), 1605-1618. 

97. Payam Mehrshahi, Sabrina Gonzalez-Jorge, Tariq Akhtar, Jane L. Ward, Anahi Santoyo-Castelazo, Susan Marcus, Aurora Lara-Núñez, Nathan Hawkins, Michael Beale, David Barrett, Paul Knox, Jesse Gregory III, Andrew Hanson, Malcolm Bennett, Dean DellaPenna (2010) Functional analysis of folate polyglutamylation and its essential role in plant metabolism and development. The Plant Journal, 64(2), 267-279.  

98 Ward, Jane.L., Baker, John M., Llewellyn, Aimee M., Hawkins, Nathaniel D., Beale, Michael H. (2011) Metabolomic analysis of Arabidopsis reveals hemiterpenoid glycosides as products of a nitrate ion-regulated, carbon flux overflow. PNAS 108(26), 10762-10767.

99. Beste, D.J.V., Bonde, B., Hawkins, N., Ward, J.L., Beale, M.H., Noack, S., Noeh, K., Kruger, N.J., Ratcliffe, R.G., McFadden, J. (2011) (13)C Metabolic Flux Analysis Identifies an Unusual Route for Pyruvate Dissimilation in Mycobacteria which Requires Isocitrate Lyase and Carbon Dioxide Fixation. Plos Pathogens 7(7), article no: e1002091  

100. Simon Hodge, Jane L. Ward, Aimee M. Galster, Michael H. Beale, Glen Powell (2011) The effects of a plant defence priming compound, beta-aminobutyric acid, on multitrophic interactions with an insect herbivore and a hymenopterous parasitoid. Biocontrol, 56, 699-711.  

101 P John Andralojc, Pippa J Madgwick, Alfred J Keys, Jane L Ward, Michael H Beale, Jane E Loveland, Philip J Jackson, Antony C Willis, Steven Gutteridge and Martin AJ Parry (2012) CA1P phosphatase – evidence for a wider role in plant Rubisco regulation. The Biochemical Journal  442:733-742

102. Delia-Irina Corol, Catherine Ravel, Mariann Raksegi, Zoltan Bedo, Gilles Charmet Michael H. Beale, Peter R. Shewry and Jane L. Ward. (2012) Effects of genotype and environment on the contents of betaine, choline and trigonelline in cereal grain. J. Agric. Food Chem. 60, 5471-5481

103 Jared Criswell, Kevin Potter, Freya Shephard, Michael H Beale, Reuben J Peters (2012) A Single Residue Change Leads to a Hydroxylated Product from the Class II Diterpene Cyclization Catalyzed by Abietadiene Synthase. Organic letters, 14, 5828–5831

104  Stephane Bernillon, Benoit Biais, Catherine Deborde, Mickael Maucourt, Cecile Cabasson, Yves Gibon, Thomas H. Hansen, Soren Husted, Ric C.H. de Vos, Roland Mumm, Harry Jonker, Jane L. Ward, Sonia J. Miller, John M. Baker, Joseph Burger, Ya’akov Tadmor, Michael H. Beale, Jan K. Schjoerring, Arthur A. Schaffer, Dominique Rolin, Robert D. Hall, annick Moing (2013) Metabolomic and elemental profiling of melon fruit quality as affected by genotype and environment. Metabolomics 9,57-77 

105 Simon Hodge Jane L. Ward, Michael H. Beale, Mark Bennett, John W. Mansfield and Glen Powell (2013) Aphid-induced accumulation of trehalose in Arabidopsis thaliana  is systemic and dependent upon aphid density. Planta, 237, 1057-1064.(DOI 10.1007/s00425-012-1826-4)

106  Michael H. Beale and Jane L. Ward. (2013) Hemiterpenoids as New Players in the Carbon-Nitrogen Economy. Recent Advances in Phytochemistry 43, 1-20

107  I.M. Scott, W. Lin, M. Liakata, J.E. Wood, C.P. Vermeer, D. Allaway, J.L. Ward, J. Draper, M.H. Beale, D.I. Corol, J.M. Baker, R.D. King (2013). Merits of random forests emerge in evaluation of chemometric classifiers by external validation. Analytica Chimica Acta, 801, 22-33.

108 Dany JV Beste, Katherina Noh, Sebastian Niedenfuhr, Tom A Mendum, Nathanial D Hawkins, Jane L Ward, Michael H Beale, Wolfgang Wiechart, Johnjoe McFadden. (2013) Carbon fixation and a mixed diet for the intra cellular tuberculosis bacillus. 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis. Cell:Chemistry and Biology, 20, 1012–1021.

109 David J Studholme, Beverley Harris, Kate Le Cocq, Rebecca Winsbury, Venura Perera, Lauren Ryder, Michael H. Beale, Jane L. Ward, Christopher R. Thornton, Murray Grant (2013). Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture—insights from genomics. Frontiers in Plant Science, 4, 258-.  doi: 10.3389/fpls.2013.00258.

110  Laura Perez-Fons, Tom Wells, Delia I.Corol, Jane L. Ward, Christopher Gerrish, Michael H. Beale, Graham B Seymour, Peter M. Bramley and Paul D Fraser. (2014) A genome-wide metabolomic resource for tomato fruit from Solanum pennellii  Nature:Scientific Reports, 4 : 3859 | DOI: 10.1038/srep03859 

111  Ian Scott, Jane Ward, Sonia Miller, Michael Beale. (2014) Opposite variations in fumarate and malate dominate metabolic phenotypes of Arabidopsis salicylate mutants with abnormal biomass under chilling. Physiologia Plantarum. (In Press) 


b) Book Chapters and Conference Proceedings 

1.  Beale, M.H. and MacMillan, J. (1983). 2,2-Dimethylgibberellin A4, a Powerful Growth Regulator ,In Proceedings 3rd Symposium on Plant Growth Regulators, Varna, Bulgaria, 1981.  Eds. D. Lilov, E. Karanov, L. Iliev, Bulgarian Academy of Sciences, Sofia , p. 108.

2. Beale, M.H., Hooley, R. and MacMillan, J. (1986). Gibberellins: Structure-Activity Relationships and the Design of Molecular Probes. Plant Growth Substances 1985, Proceedings of the 12th International Conference on Plant Growth Substances, Heidelberg . Ed. M. Bopp, Springer-Verlag, pp 65-73.

3. Beale, M.H. (1990). The Preparation and Uses of Anti-gibberellin Monoclonal Antibodies. In Molecular Aspects of the Hormonal Regulation of Plant Development, Proceedings of the 14th International Congress of Biochemistry, Prague (Eds. M. Kutachek, M.C. Elliot and I. Machackova, SPB Academic Publishing, The Hague p.31

4. Hooley, R., Beale, M.H., Smith, S.J. and MacMillan, J. (1990). Novel Affinity Probes for Gibberellin Receptors in Aleurone Protoplasts of Avena fatua. In Plant Growth Substances 1988, Proceedings of the 13th International Conference on Plant Growth Substances, Calgary (Eds. R.P. Pharis and S.B. Rood) Springer-Verlag. 146.

5. Hooley, R., Beale, M.H. & Walker, R.P. (1990). Gibberellin perception in the Avena Fatua aleurone. Physiologia Plantarum 79, 31

6. Hooley, R., Beale, M.H. and Smith, S.J. (1990). Gibberellin Perception in the Avena fatua Aleurone. In SEB Seminar Series 44, Eds. J. Roberts, C. Kirk and M. A. Venis, 79-86. (20,20,0)

7. Hooley, R., Beale, H.M. and Smith, S.J. (1991). Probing Gibberellin Receptors in the Avena fatua Aleurone. In Gibberellins (Eds. N. Takahashi, B.O. Phinney and J. MacMillan). Springer-Verlag, pp. 136-145.

8. Beale, M.H. and Willis, C.L. (1991). The Gibberellins. In Methods in Plant Biochemistry Vol. 7, Terpenoids (Eds. D. Banthorpe and B. Charlwood) Academic Press, pp. 289-330.

9. Hooley, R., Beale, M.H., Smith, S.J., Walker , R.P., Rushton, P.J., Whitford, P.N. and Lazarus, C.M. (1992). Gibberellin perception and the Avena fatua aleurone: do our molecular keys fit the correct locks? Biochem. Soc. Trans., 20, 85.

10. Beale, M.H., Ward, J.L., Smith, S.J. and Hooley, R. (1992). A New Approach to Gibberellin Perception in Aleurone:- Novel Hydrophilic, Membrane-impermeant , GA -Sulphonic Acid Derivatives Induce α-Amylase. Physiol. Plant., 85, A24. (

11. Hooley, R., Beale, M.H., Smith, S.J., and Walker, R.P. (1992). Photoaffinity Labelling of Gibberellin-binding Proteins in Avena fatua Aleurone. Physiol. Plant., 85, A27.

12. Hooley, R., Beale, M.H., Smith, S.J., Walker , R.P., Rushton, P.J., Whitford, P.N. and Lazarus, C.M. (1992) Hormone Perception and Signal Transduction in Aleurone. In Transport and Receptor Proteins of Plant Membranes. (Eds. Cooke, D.T. and Clarkson, D.T.). Plenum Press, New York , pp. 157-167.

13. Cooper, R.M., Flood, J., Rowan, M.G., Resende, M.L.V. and Beale, M.H. (1995) The Role of Tannins and phytoalexins in the Resistance of Cocoa (Threobroma cacao L.) to Verticillium dahliae. Aspects of Applied Biology, 42, 315-322. (

14. Hooley, R., Beale, M. H., Lovegrove, A., Barratt, D. H. P., Smith, S. J., Jones, H. D. & Plakidou-Dymock, S. (1996). Hormone perception and signal transduction in aleurone. Journal of Experimental Botany 47 (Supplement), 2

15. Lovegrove, A., Barratt, D. H. P., Beale, M. H. & Hooley, R. (1996). Gibberellin binding proteins in oat aleurone and leaf plasma membrane. Journal of Experimental Botany 47 (Supplement), 5.

16. Allan AC, Ward JL, Beale MH, Trewavas AJ (1998) Caged Plant Growth Regulators. In Methods in Enzymol 291 (ed G Marriott) 474-483. Academic Press London.

17. Tiekstra, A. E., Beale, M. H., Else, M. A. & Jackson, M. B. (1998). Characterizing anti-transpirant activity in xylem sap of flooded and well-drained tomato plants. Journal of Experimental Botany 49 (Supplement), 33.

18. Hedden, P., Phillips, A. L., Coles, J. P., Thomas, S. G.,Appleford, N. E. J., Brown, R. G. S., Ward, D. A., Ward, J. L., Beale, M. H. & Lenton, J. R. (1998). The dioxygenases of gibberellin biosynthesis: function, regulation and genetic manipulation. In Abstracts 16th International Conference on Plant Growth Substances, Chiba, Japan, 13-17 August 1998 47.

19. Beale, M. H., Ward, J. L. & Kohler, A. D. (1998). Molecular probes for physiological action of plant hormones. In Abstracts 16th International Conference on Plant Growth Substances, Chiba, Japan, 13-17 August 1998 56.

20. MacMillan, J. and Beale M.H. (1999) Diterpene Biosynthesis. In Comprehensive Natural Products Chemistry, Vol 2, Isoprenoids including Carotenoids and Steroids, ed D.E.Cane, Elsevier,1999, pp217-243

21. Beale, M.H. (1999). Immunological Methods of Plant Hormone Analysis. In Biochemistry and Molecular Biology of Plant Hormones (New Comprehensive Biochemistry Vol 33), (Eds. Hooykas, P. J. J., Hall, M. A. and Libbenga, K. R.) Elsevier. pp61-88.

22. Stavropoulos, E. V., Beale, M. H. & Trewavas, A. J. (1999). Construction and expression of a green fluorescent protein binding indicator. Journal of Experimental Botany 50 (Supplement), 75.

23 Beale,M.H., Shewry, P.R and Napier, J.A. (2003) Production of High-value Chemicals in Plants. In Long Ashton Research Station:- 100 years of science in support of agriculture. (Eds Anderson, H. M., Lenton, J. R. and Shewry, P.R.) University of Bristol , Long Ashton Research Station. pp284-290.

24 Lewis, J., Baker, J. Beale, M.H. and Ward, J. L. (2004) Metabolite Profiling of GM Plants: The Importance of Robust Experimental Design and Execution. In Genomics for Biosafety in Plant Biotechnology (Eds Nap, J.P.H., Atanassov, A and Stiekema, W.J) IOS Press, Amsterdam pp47-57.

25 Humphrey A. J. and Beale M. H. (2005) Terpenes. In Plant Secondary Metabolites. Occurrence, structure and role in diet and health (eds Alan Crozier, Mike Clifford and Hiroshi Ashihara) Blackwells, Oxford pp 47 -101

26. Jane L. Ward and Michael H. Beale (2005) NMR Spectroscopy in Plant Metabolomics, In Plant Metabolomics, Biotechnology in Agriculture and Forestry series, (eds K. Saito, R. Dixon and L. Willmitzer) Springer, Heidelberg. Pp 81-91

27. Jane L. Ward and Michael H. Beale. Proceedings of 4th International Conference on Plant Metabolomics. (2006) Metabolomics Journal 2, 269-334

28 Michael H. Beale and Jane Ward (2009) Establishing substantial equivalence: metabolomics,  In Methods in Biotechnology – Transgenic Wheat, Barley and Oats: production and characterization. (Eds H. W. Jones and P. R. Shewry) Humana Press pp 289-303

29 Li Li, Claudia Harflett, Michael H. Beale and Jane L. Ward. (2009) Phenolic acids, In Analysis of Bioactive Components in Small Grain Cereals (Eds Peter R. Shewry and Jane L. Ward. Published by AACC International, Minnesota, USA), 41-52

30. Michael H Beale and Michael R Sussman (2011) Metabolomics of Arabidopsis, In Annual Plant Reviews: The Biology of Plant Metabolomics, Ed R Hall, Wiley-Blackwell. pp157-180 

31. Aimee M. Galster, Jennie Lewis, Sonia J. Miller, Delia-Irina Corol, Michael H. Beale and Jane L. Ward.(2012) Tissue Preparation using Arabidopsis . In Plant Metabolomics,  Methods in Molecular Biology Series, Eds Nigel Hardy and Robert Hall, Humana Press, Totowa, NJ pp 65-81

32. John M. Baker, Jane L. Ward and Michael H. Beale. (2012) Combined NMR and Flow Injection ESI-MS for Brassicaceae metabolomics In Plant Metabolomics,  Methods in Molecular Biology Series, Eds Nigel Hardy and Robert Hall, Humana Press, Totowa, NJ pp177-191

33. Michael H. Beale, Jane L Ward (2013) Hemiterpenoids as New Players in the Carbon-nitrogen economy Recent Advances in Phytochemistry 43:1-20.


c) Other publications

 Beale, M.H. and MacMillan, J. (1980-1). Dehydroxylation of 13-Hydroxy- gibberellins. Brit. Patent App. 78/30183, Eur. Patent Appl. 7240, U.S. Patent Appl. 963743. (Chem. Abst. 93, 72031).

Bouwmeester HJ, Matusova R Sun, Z. Beale. M. H and Franssen, M (2005) Resistance against parasitic weeds P217578EP