Biointeractions and Crop Protection
molecular entomology, insect migration, phenotype:genotype associations in insect pests
I am a molecular entomologist with experience working on insects of medical and agricultural importance. During my time as an undergraduate at Durham University (2002-2005) I generated an interest in insect borne diseases and then went on to obtain an MSc in the Biology and Control of Disease Vectors at the London School of Tropical Medicine & Hygiene (2005-2006). In 2006 I was awarded an industrial CASE PhD studentship at Rothamsted Research in partnership with Syngenta and the University of Nottingham. Under the supervision of Dr Ian Denholm/Martin Williamson (Rothamsted) and Prof. John Brookfield (University of Notthingham), I studied the molecular basis of insecticide resistance in the whitefly, Bemisia tabaci. This led to a three-year post-doctoral position in Prof. Hilary Ranson’s group at the Liverpool School of Tropical Medicine (LSTM). At LSTM I developed and established DNA and RNA diagnostics for insecticide resistance in the African malaria vector, Anopheles gambiae bridging the gap between field and lab work.
I am currently leading a project at Rothamsted Research to study the genetic basis of insect migration in Noctuid moth pests (e.g. the cotton bollworm, Helicoverpa armigera). Noctuid moths can undertake migratory journeys up to thousands of kilometres in length in search of more favourable habitats. Sometimes it can take more than one generation to complete a journey and so there must be an inherent genetic basis to this phenomenon. Using flight bioassays at Rothamsted we are currently trying to distinguish between long-range (migratory) and short-range (sedentary) insect fliers. We can then use state-of-the-art molecular tools to decipher which genes are responsible for these remarkable journeys. I am currently supervised by Dr Jason Chapman (head of the Insect Migration & Spatial Ecology group) and Dr Chris Bass (Institute Career Path Fellow in the Pesticide Resistance group).
Toe K. Hyacinthe (based at LSTM and CNRFP (Burkina Faso), co-supervisor with Prof. Hilary Ranson): Characterisation of insecticide resistance in malaria vectors from Valle de Kou, Burkina Faso and its impact on current control strategies
Phone:+44 (0) 1582 763 133 ext: +44 1582 938431
Location:Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
- IDG Helicoverpa Armigera
Christopher M Jones, Khamis A Haji, Bakari O Khatib, Judit Bagi, Juma Mcha, Gregor J Devine, Matthew Daley, Bilali Kabula, Abdullah S Ali, Silas Majambere and Hilary Ranson (2013). The dynamics of pyrethroid resistance in Anopheles arabiensis from Zanzibar and an assessment of the underlying genetic basis. Parasites & Vectors, 6: 343 doi:10.1186/1756-3305-6-343
N. Yang, W. Xie, Christopher M. Jones, Chris Bass, X. Jiao, X. Yang, B. Liu, R. Li and Y. Zhang (2013) Transcriptome profiling of the whitefly Bemisia tabaci reveals stage-specific gene expression signatures for thiamethoxam resistance Insect Molecular Biology, 22: 485-496 doi: 10.1111/imb.12038
Muhammad Asam Riaz, Alexia Chandor-Proust, Chantal Dauphin-Villemant, Rodolphe Poupardin, Christopher M. Jones, Clare Strode, MyriamRegent-Kloeckner, Jean-Philippe David & Stephane Reynaud (2013) Molecular mechanisms associated with increased tolerance to the neonicotinoid insecticide imidacloprid in the dengue vector Aedes aegypti. Aquatic Toxicology, 126: 326-337 doi:10.1016/j.aquatox.2012.09.010
Rachel M. Kwiatkowska, Naomi Platt, Rodolphe Poupardin, Helen Irving, Roch K. Dabire, Sara Mitchell, Christopher M. Jones, Abdoulaye Diabaté, Hilary Ranson & Charles S. Wondji (2013) Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae s.s., M form, from Vallée du Kou, Burkina Faso. Gene, 519(1): 98-106
Constant V.A. Edi, Benjamin G. Koudou, Christopher M. Jones, David Weetman & Hilary Ranson (2012) Multiple-Insecticide Resistance in Anopheles gambiae Mosquitoes, Southern Côte d’Ivoire. Emerging Infectious Diseases, 18(9): 1508-1511 doi:10.3201/eid1809.120262
Christopher M. Jones, Hyacinthe K. Toè, Antoine Sanou, Moussa Namountougou, Angela Hughes, Abdoulaye Diabaté, Roch Dabirè, Fred Simard & Hilary Ranson. Additional Selection for Insecticide Resistance in Urban Malaria Vectors: DDT Resistance in Anopheles arabiensis from Bobo-Dioulasso, Burkina Faso. PLoS One, 7(9): doi:10.1371/journal.pone.0045995
Athanase Badolo, Alphonse Traoré, Christopher M. Jones, Antoine Sanou, Lori Flood, Wamdaogo Moussa Guelbéogo, Hilary Ranson & N’Falé Sagnon (2012) Three years of insecticide resistance monitoring in Anopheles gambiae in Burkina Faso: resistance on the rise? Malaria Journal, in press.
Guillaume Tetreau, Krishnareddy Bayyareddy, Christopher M Jones, Renaud Stalinski, Muhammad A Riaz, Margot Paris, Jean-Philippe David, Michael J Adang & Laurence Després (2012) Larval midgut modifications associated with Bti resistance in the yellow fever mosquito using proteomic and transcriptomic approaches. BMC Genomics, 13: 248 doi:10.1186/1471-2164-13-248
Vassiliki Bariami, Christopher M. Jones, Rodolphe Poupardin, John Vontas & Hilary Ranson (2012) Gene Amplification, ABC Transporters and Cytochrome P450s: Unraveling the Molecular Basis of Pyrethroid Resistance in the Dengue Vector, Aedes aegypti. PLoS Neglected Tropical Diseases, 6(6): e1692.
Christopher M. Jones, Camille Machin, Khalfan Mohammed, Silas Majambere, Abdullah S. Ali, Bakari O. Khatib, Juma Mcha, Hilary Ranson & Louise A. Kelly-Hope (2012) Insecticide resistance in Culex quinquefasciatus from Zanzibar: implications for vector control programmes. Parasites & Vectors, 5 (1): 78
Christopher M. Jones, Milindu Liyanapathirana, Fiacre R. Agossa, David Weetman, Hilary Ranson, Martin James Donnelly & Craig Wilding (2012) Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae. Proceedings of the National Academy of Sciences, 109(17): 6614-6619
Rodolphe Poupardin, Muhammad Asam Riaz, Christopher M. Jones, Alexia Chandor-Proust, Stéphane Reynaud & Jean-Phillipe David (2012) Do pollutants affect insecticide-driven gene selection in mosquitoes? Experimental evidence from transcriptomics. Aquatic Toxicology, 114 (11): 49-57.
Christopher M. Jones, Antoine Sanou, Wamdaogo M. Guelbeogo, N’Fale Sagnon, Paul C.D. Johnson, & Hilary Ranson (2012) 'Aging partially restores the efficacy of malaria vector control in insecticide-resistant populations of Anopheles gambiae s.l. from Burkina Faso'. Malaria Journal, 11(1): 24
Yousif E. Himeidan, Hamid Muzamil, Christopher M. Jones, & Hilary Ranson (2011) 'Extensive permethrin and DDT resistance in Anopheles arabiensis from eastern and central Sudan'. Parasites & Vectors, 4(1): 154.
Christopher M. Jones, Miriam Daniels, Melanie Andrews, Russell Slater, Robert J. Lind, Kevin Gorman, Martin S. Williamson, & Ian Denholm (2011) Age-specific expression of a P450 monooxygenase (CYP6CM1) correlates with neonicotinoid resistance in Bemisia tabaci. Pesticide Biochemistry and Physiology, 101: 53-58.
Chen Luo, Christopher M. Jones, Greg Devine, Fan Zhang, Ian Denholm, & Kevin Gorman (2009) Insecticide resistance in Bemisia tabaci biotype Q (Hemiptera: Aleyrodidae) from China. Crop Protection, 29: 429-434.
Christopher M. Jones, Kevin Gorman, Ian Denholm, & Martin S. Williamson (2008) High-throughput allelic discrimination of B and Q biotypes of the whitefly, Bemisia tabaci, using TaqMan allele-selective PCR. Pest Management Science, 64: 12-15.